600-401-DU8
PTPN5 Antibody
Cannot supply to this region.
- SKU:
- 600-401-DU8
- Additional Names:
- PTPN5|Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, PTPSTEP, Striatum-enriched protein-tyrosine phosphatase, STEP
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PTPN5 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the N-terminus of human PTPN5.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q86TL6
- Synonyms:
- neural-specific protein-tyrosine phosphatase;protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched);protein-tyrosine phosphatase striatum-enriched;PTPSTEP;STEP;STEP61;striatal-enriched protein tyrosine phosphatase;striatum-enriched protein-tyrosine phosphatase;tyrosine-protein phosphatase non-receptor type 5
- Extra Details:
- The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).
- Shipping Conditions:
- Dry Ice