600-401-DP8
PKR Antibody
Cannot supply to this region.
- SKU:
- 600-401-DP8
- Additional Names:
- EIF2AK2|PKR Antibody, PKR, PRKR, EIF2AK1, PKR, Interferon-induced, double-stranded RNA-activated protein kinase, Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PKR antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 14 amino acids near the N-terminus of human PKR. The immunogen is located within the first 50 amino acids of PKR.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P19525
- Synonyms:
- double stranded RNA activated protein kinase;eIF-2A protein kinase 2;EIF2AK1;Eukaryotic translation initiation factor 2-alpha kinase 2;interferon-induced, double-stranded RNA-activated protein kinase;interferon-inducible elF2alpha kinase;Interferon-inducible RNA-dependent protein kinase;LEUDEN;P1/eIF-2A protein kinase;p68 kinase;PKR;PPP1R83;PRKR;protein kinase R;Protein kinase RNA-activated;protein kinase, interferon-inducible double stranded RNA dependent;protein phosphatase 1, regulatory subunit 83;tyrosine-protein kinase EIF2AK2
- Extra Details:
- The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
- Shipping Conditions:
- Dry Ice