600-401-DL7
PHAP I Antibody
Cannot supply to this region.
- SKU:
- 600-401-DL7
- Additional Names:
- ANP32A|PHAP I Antibody, LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PHAP I antibody was raised with a synthetic peptide corresponding to amino acids close to C-terminus of human PHAP I. This sequence is identical between human and rat PHAP I.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P39687
- Synonyms:
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member A;acidic leucine-rich nuclear phosphoprotein 32 family member A;acidic nuclear phosphoprotein pp32;C15orf1;cerebellar leucine rich acidic nuclear protein;epididymis secretory sperm binding protein;hepatopoietin Cn;HPPCn;I1PP2A;inhibitor-1 of protein phosphatase-2A;LANP;leucine-rich acidic nuclear protein;MAPM;mapmodulin;PHAP1;PHAPI;potent heat-stable protein phosphatase 2A inhibitor I1PP2A;PP32;putative HLA-DR-associated protein I;putative human HLA class II associated protein I
- Extra Details:
- Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
- Shipping Conditions:
- Dry Ice