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Nudel Antibody

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  2. Polyclonal

600-401-DF0

Nudel Antibody

Cannot supply to this region.

SKU:
600-401-DF0
Additional Names:
NDEL1|Nudel Antibody, EOPA, NDE2, NUDEL, MITAP1, NDE1L1, EOPA, Nuclear distribution protein nudE-like 1, Mitosin-associated protein 1, Protein Nudel
Application:
ELISA, IHC, WB, IF
Concentration:
1 mg/ml
Physical State:
Liquid
Species Reactivity:
Human
Storage Conditions:
-20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:
Rockland Inc
Host:
Rabbit
Reactivities:
Human, Mouse
Buffer:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:
Anti-Nudel antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 15 amino acids near the N-terminus of human Nudel.
Formulation:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:
Q9GZM8
Synonyms:
endooligopeptidase A;EOPA;MITAP1;mitosin-associated protein 1;mitosin-associated protein MITAP1;NDE1L1;NDE2;nuclear distribution protein nudE-like 1;nudE nuclear distribution E homolog-like 1;nudE nuclear distribution gene E homolog-like 1;NUDEL;protein Nudel
Extra Details:
Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration. It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology. It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions. Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus.
Shipping Conditions:
Dry Ice