600-401-DA2
Neuritin Antibody
Cannot supply to this region.
- SKU:
- 600-401-DA2
- Additional Names:
- Neuritin Antibody, NRN, dJ380B8.2, NRN, Neuritin|NRN1
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Neuritin antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid synthetic peptide from near the internal region of human neuritin.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9NPD7
- Synonyms:
- dJ380B8.2;neuritin;NRN
- Extra Details:
- As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
- Shipping Conditions:
- Dry Ice