IRF8 Antibody

Cannot supply to this region.

SKU:: 600-401-CA5
Additional Names:: IRF8|IRF8 Antibody, Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP
Application:: ELISA, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-IRF8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 16 amino acids near the C-terminus of human IRF8.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q02556
Synonyms:: H-ICSBP;ICSBP;ICSBP1;IMD32A;IMD32B;interferon consensus sequence binding protein 1;Interferon consensus sequence-binding protein;interferon regulatory factor 8;IRF-8
Extra Details:: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-kB by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

Shipping Conditions:: Dry Ice