600-401-BT8
IKAP Antibody
Cannot supply to this region.
- SKU:
- 600-401-BT8
- Additional Names:
- ELP1|IKAP Antibody, FD, DYS, ELP1, IKI3, TOT1, Elongator complex protein 1, IkappaB kinase complex-associated protein, IKK complex-associated protein, p150
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-IKAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human IKAP.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O95163
- Synonyms:
- DYS;elongator complex protein 1;FD;IKAP;ikappaB kinase complex-associated protein;IKBKAP;IKI3;IKK complex-associated protein;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein;p150;TOT1
- Extra Details:
- IKAP was initially identified as a scaffold protein of the IkB kinase complex that could bind to IKKa, IKKb, NF-kB, and the NF-kB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.
- Shipping Conditions:
- Dry Ice