600-401-BS5
IA1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-BS5
- Additional Names:
- IA-1 Antibody, IA1, IA-1, IA1, Insulinoma-associated protein 1, Zinc finger protein IA-1, INSM1, INSM Transcriptional Repressor 1, Zinc Finger Protein IA-1, Insulinoma-Associated 1, IA1, Insulinoma-Associated Protein 1, Insulinoma Associated 1, IA-1|INSM1
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-IA-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide from near the N-terminus of human IA-1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q01101
- Synonyms:
- IA-1;IA1;insulinoma-associated 1;insulinoma-associated protein 1;zinc finger protein IA-1
- Extra Details:
- IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
- Shipping Conditions:
- Dry Ice