600-401-BL0
GITRL Antibody
Cannot supply to this region.
- SKU:
- 600-401-BL0
- Additional Names:
- GITRL Antibody, TL6, AITRL, GITRL, hGITRL, TL6, UNQ149/PRO175, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand|TNFSF18
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-GITRL antibody was prepared from whole rabbit serum produced by repeated immunizations with purified recombinant human GITR ligand.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9UNG2
- Synonyms:
- activation-inducible TNF-related ligand;AITR ligand;AITRL;GITR ligand;GITRL;glucocorticoid-induced TNF-related ligand;glucocorticoid-induced TNFR-related protein ligand;hGITRL;TL6;TNLG2A;tumor necrosis factor (ligand) superfamily, member 18;tumor necrosis factor ligand 2A;tumor necrosis factor ligand superfamily member 18;tumor necrosis factor superfamily member 18
- Extra Details:
- The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.
- Shipping Conditions:
- Blue Ice