600-401-BH0
FOXRED2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-BH0
- Additional Names:
- FOXRED2|FOXRED2 Antibody, ERFAD, ERFAD, FAD-dependent oxidoreductase domain-containing protein 2, Endoplasmic reticulum flavoprotein associated with degradation
- Application:
- ELISA, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-FOXRED2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the N-terminus of human FOXRED2.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q8IWF2
- Synonyms:
- endoplasmic reticulum flavoprotein associated with degradation;ER flavoprotein associated with degradation;ERFAD;FAD-dependent oxidoreductase domain-containing protein 2
- Extra Details:
- FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.
- Shipping Conditions:
- Dry Ice