FKBP15 Antibody

Cannot supply to this region.

SKU:: 600-401-BE9
Additional Names:: FKBP15|FKBP15 Antibody, FKBP133, PPP1R76, KIAA0674, FK506-binding protein 15, 133 kDa FK506-binding protein, FKBP-15
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-FKBP15 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the N-terminus of human FKBP15.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q5T1M5
Synonyms:: 133 kDa FK506-binding protein;133 kDa FKBP;FK506 binding protein 15, 133kDa;FK506-binding protein 133kDa;FK506-binding protein 15;FKBP prolyl isomerase 15;FKBP-133;FKBP-15;FKBP133;KIAA0674;PPP1R76;protein phosphatase 1, regulatory subunit 76;WAFL;WASP and FKBP-like protein;WASP- and FKBP-like protein
Extra Details:: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosuppressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

Shipping Conditions:: Dry Ice