600-401-BB1
EPAC1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-BB1
- Additional Names:
- EPAC1 Antibody, EPAC, EPAC1, bcm910, HSU79275, CAMP-GEFI, CGEF1, EPAC, Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, EPAC 1|RAPGEF3
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-EPAC1 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the N-terminus of human EPAC1.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O95398
- Synonyms:
- 9330170P05Rik;bcm910;CAMP-GEFI;cAMP-regulated guanine nucleotide exchange factor I;EPAC;EPAC 1;EPAC1;exchange factor directly activated by cAMP 1;exchange protein directly activated by cAMP 1;HSU79275;Rap guanine nucleotide exchange factor (GEF) 3;rap guanine nucleotide exchange factor 3;Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
- Extra Details:
- EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signaling, ion transporter activity, and exocytosis.
- Shipping Conditions:
- Dry Ice