600-401-AZ6
EI24 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AZ6
- Additional Names:
- EI24|EI24 Antibody, EPG4, PIG8, TP53I8, p53-induced gene 8 protein
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-EI24 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the C-terminus of human EI24.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O14681
- Synonyms:
- ectopic P-granules autophagy protein 4 homolog;EPG4;etoposide induced 2.4;etoposide-induced protein 2.4 homolog;p53-induced gene 8 protein;PIG8;TP53I8;tumor protein p53 inducible protein 8
- Extra Details:
- The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
- Shipping Conditions:
- Dry Ice