600-401-AZ3
EFCAB4B Antibody
Cannot supply to this region.
- SKU:
- 600-401-AZ3
- Additional Names:
- CRACR2A|EFCAB4B Antibody, CRACR2A, CRACR2A, EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-EFCAB4B antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human EFCAB4B.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9BSW2
- Synonyms:
- Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A;calcium release-activated calcium channel regulator 2A;Calcium release-activated channel regulator 2A;CRAC channel regulator 2A;CRAC regulator 2A;EF-hand calcium binding domain 4B;EF-hand calcium-binding domain-containing protein 4B;EFCAB4B;RAB46;ras-related protein Rab-46
- Extra Details:
- EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.
- Shipping Conditions:
- Dry Ice