600-401-AY6
EBI3 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AY6
- Additional Names:
- EBI3|EBI3 Antibody, IL27B, IL-27B, IL27B, Interleukin-27 subunit beta, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-EBI3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the internal region of human EBI3.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q14213
- Synonyms:
- cytokine receptor;EBV-induced gene 3 protein;Epstein-Barr virus induced gene 3;epstein-Barr virus-induced gene 3 protein;IL-27 subunit beta;IL-27B;IL27 subunit;IL27B;IL35 subunit;IL35B;interleukin-27 subunit beta
- Extra Details:
- EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35. Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
- Shipping Conditions:
- Dry Ice