DTX4 Antibody

Cannot supply to this region.

SKU:: 600-401-AY1
Additional Names:: Deltex 4 E3 ubiquitin ligase, RNF155|DTX4
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-DTX4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the internal region of human DTX4.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q9Y2E6
Synonyms:: deltex 4 homolog;deltex 4, E3 ubiquitin ligase;deltex homolog 4;deltex4;E3 ubiquitin-protein ligase DTX4;protein deltex-4;RING finger protein 155;RING-type E3 ubiquitin transferase DTX4;RNF155
Extra Details:: The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).