600-401-AV7
DIS3 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AV7
- Additional Names:
- DIS3|DIS3 Antibody, RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-DIS3 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the N-terminus of human DIS3.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9Y2L1
- Synonyms:
- 2810028N01Rik;DIS3 exosome endoribonuclease and 3'-5' exoribonuclease;DIS3 mitotic control homolog;dis3p;EXOSC11;exosome complex exonuclease RRP44;exosome component 11;KIAA1008;mitotic control protein dis3 homolog;Protein DIS3 homolog;ribosomal RNA-processing protein 44;RRP44
- Extra Details:
- The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
- Shipping Conditions:
- Dry Ice