600-401-AV2
DFF40 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AV2
- Additional Names:
- DFF40 Antibody, CAD, CPAN, DFF2, DFF-40, Didff, 5730477D02Rik, Cad, DNA fragmentation factor subunit beta, CAD, Caspase-activated deoxyribonuclease, Caspase-activated DNase, Caspase-activated nuclease, DNA fragmentation factor 40 kDa subunit|DFFB
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-DFF40 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid peptide near the N-terminus of human DFF40.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O76075
- Synonyms:
- CAD;caspase-activated deoxyribonuclease;caspase-activated DNase;caspase-activated nuclease;CPAN;DFF-40;DFF2;DFF40;DNA fragmentation factor 40 kDa subunit;DNA fragmentation factor subunit beta;DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- Extra Details:
- Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease. The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively. DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.
- Shipping Conditions:
- Dry Ice