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CDKN2A Antibody

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  2. Polyclonal

600-401-AJ9

CDKN2A Antibody

Cannot supply to this region.

SKU:
600-401-AJ9
Additional Names:
CDKN2A|CDKN2A Antibody, ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A
Application:
ELISA, IHC, WB, IF
Concentration:
1 mg/ml
Physical State:
Liquid
Species Reactivity:
Human
Storage Conditions:
2-8[o]C
Supplier:
Rockland Inc
Host:
Rabbit
Reactivities:
Human, Mouse, Rat
Buffer:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:
Anti-CDKN2A antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide from near the N-terminus of human CDKN2A.
Formulation:
0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:
P42771
Synonyms:
alternative reading frame;ARF;CDK4 inhibitor p16-INK4;CDK4I;CDKN2;cell cycle negative regulator beta;CMM2;cyclin-dependent kinase 4 inhibitor A;cyclin-dependent kinase inhibitor 2A;cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4);INK4;INK4A;MLM;MTS-1;MTS1;multiple tumor suppressor 1;P14;P14ARF;P16;P16-INK4A;P16INK4;P16INK4A;P19;P19ARF;TP16
Extra Details:
The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.
Shipping Conditions:
Blue Ice