600-401-AH8
CHCHD6 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AH8
- Additional Names:
- CHCHD6|CHCHD6 Antibody, CHCM1, PPP1R23, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti- CHCHD6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the N-terminus of human CHCHD6.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9BRQ6
- Synonyms:
- CHCM1;coiled coil helix cristae morphology 1;coiled-coil-helix cristae morphology protein 1;Coiled-coil-helix-coiled-coil-helix domain-containing protein 6;coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial;Mic25;MICOS complex subunit MIC25;MICOS25;mitochondrial contact site and cristae organizing system subunit 25;PPP1R23;protein phosphatase 1, regulatory subunit 23
- Extra Details:
- CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
- Shipping Conditions:
- Dry Ice