600-401-AG2
CCP110 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AG2
- Additional Names:
- CCP110|CCP110 Antibody, CP110, Cep110, CEP110, CP110, KIAA0419, Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-CCP110 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human CCP110.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- O43303
- Synonyms:
- centriolar coiled-coil protein 110kDa;centriolar coiled-coil protein of 110 kDa;centrosomal protein CP110;centrosomal protein of 110 kDa;Cep110;CP110
- Extra Details:
- CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs); disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.
- Shipping Conditions:
- Dry Ice