CCNT1 Antibody

Cannot supply to this region.

SKU:: 600-401-AG1
Additional Names:: CCNT1|rabbit anti-cyclin T1 antibody, CYCT 1 antibody, cycT1 antibody, HIVE1 antibody, Human immunodeficiency virus 1 expression antibody, CCNT1 Antibody, CCNT, CYCT1, HIVE1, Cyclin-T1, CycT1
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti- CCNT1 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the C-terminus of human CCNT1.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: O60563
Synonyms:: CCNT;CDK9-associated C-type protein;cyclin C-related protein;cyclin-T1;CYCT1;HIVE1;human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1;MLLT10/CCNT1 fusion
Extra Details:: Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Shipping Conditions:: Dry Ice