600-401-AE8
Cbl Antibody
Cannot supply to this region.
- SKU:
- 600-401-AE8
- Additional Names:
- CBL|Cbl Antibody, CBL2, NSLL, C-CBL, RNF55, FRA11B, CBL2, E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene
- Application:
- ELISA, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Cbl antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the C-terminus of human cbl.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P22681
- Synonyms:
- C-CBL;Cas-Br-M (murine) ecotropic retroviral transforming sequence;casitas B-lineage lymphoma proto-oncogene;Cbl proto-oncogene, E3 ubiquitin protein ligase;CBL2;E3 ubiquitin-protein ligase CBL;FRA11B;fragile site, folic acid type, rare, fra(11)(q23.3);NSLL;oncogene CBL2;proto-oncogene c-Cbl;RING finger protein 55;RING-type E3 ubiquitin transferase CBL;RNF55;signal transduction protein CBL
- Extra Details:
- The mammalian cbl family of ubiquitin ligases consists of three homologs known as cbl (also known as c-Cbl), Cbl-B, and Cbl-3 which share highly conserved a tyrosine-kinase-binding domain, linker and RING finger domain in their amino-terminal halves. Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitin-conjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the cbl family, cbl antibody reacts specifically with cbl. Multiple isoforms of cbl have been reported.
- Shipping Conditions:
- Dry Ice