600-401-AC0
CARMA3 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AC0
- Additional Names:
- CARD10|CARMA3 Antibody, BIMP1, CARMA3, Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3
- Application:
- ELISA, IHC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-CARMA3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the N-terminus of human CARMA3.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9BWT7
- Synonyms:
- Bcl10 binding protein and activator of NFKB;BIMP1;CARD-containing MAGUK 3 protein;CARD-containing MAGUK protein 3;carma 3;CARMA3;caspase recruitment domain-containing protein 10
- Extra Details:
- CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
- Shipping Conditions:
- Dry Ice