600-401-AB9
CARMA2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-AB9
- Additional Names:
- CARD14|CARMA2 Antibody, PRP, PSS1, BIMP2, CARMA2, PSORS2, Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2
- Application:
- ELISA, IHC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-CARMA2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human CARMA2.
- Formulation:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9BXL6
- Synonyms:
- bcl10-interacting maguk protein 2;BIMP2;CARD-containing MAGUK protein 2;CARMA2;caspase recruitment domain-containing protein 14;PRP;PSORS2;PSS1
- Extra Details:
- CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.
- Shipping Conditions:
- Dry Ice