600-401-A71
PDL1 Antibody
Cannot supply to this region.
- SKU:
- 600-401-A71
- Additional Names:
- CD274|Rabbit anti-PDL1 antibody, Rabbit Anti-Programmed cell death 1 ligand 1 Antibody, Programmed cell death ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, PD-L1, PDCD1 ligand 1, B7-H1, B7 homolog 1, PDL-1, PDL 1
- Application:
- ELISA, Flow Cytometry, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- PDL-1 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal region of human PDL-1.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9NZQ7, Q9NZQ7.1
- Synonyms:
- B7 homolog 1;B7-H;B7H1;CD274 antigen;hPD-L1;PD-L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;programmed cell death 1 ligand 1
- Extra Details:
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PDCD-1 (Programmed Cell Death 1) that mediate inhibitory signals from the APC. PDCD-1 can bind two different but related ligands, PDL-1 and PDL-2 (Programmed Cell Death Ligand -1 and -2, respectively). PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. Anti-PDL-1 antibody is ideal for investigators involved in cancer research, cytokine research, immune research and apoptosis research.
- Shipping Conditions:
- Dry Ice