600-401-A38S
THRA Antibody
Cannot supply to this region.
- SKU:
- 600-401-A38S
- Additional Names:
- rabbit anti-THRA antibody, rabbit anti-Thyroid hormone receptor alpha antibody, Nuclear receptor subfamily 1 group A member 1, c-erbA-alpha, c-erbA-1, V-erbA-related protein 7, EAR7, ERBA1, NR1A1, THRA1, THRA2|THRA
- Application:
- ChIP, ELISA, IHC, WB, IF, IP
- Concentration:
- 0.89 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- P10827-2
- Synonyms:
- AR7;c-ERBA-1;c-erbA-alpha;CHNG6;EAR-7;EAR7;ERB-T-1;ERBA;ERBA-related 7;ERBA1;NR1A1;nuclear receptor subfamily 1 group A member 1;THRA1;THRA2;thyroid hormone receptor alpha;thyroid hormone receptor alpha 1;thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian);thyroid normone nuclear receptor alpha variant 1;TRalpha;triiodothyronine receptor;V-erbA-related protein 7
- Extra Details:
- This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. Isoform 1 has a distinct C-terminus compared to isoform 2.
- Shipping Conditions:
- Dry Ice