600-401-849
GGA2 Antibody
Cannot supply to this region.
- SKU:
- 600-401-849
- Additional Names:
- GGA2|rabbit anti-GGA-2 antibody, GGA2, GGA 2, Golgi associated gamma adaptin ear containing ARF binding protein 2, ADP-ribosylation factor-binding protein GGA2, Gamma-adaptin-related protein 2, VHS domain and ear domain of gamma-adaptin, Vear
- Application:
- ELISA, WB, IP
- Concentration:
- 1.4 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 240-270 of Human GGA2. SwissProt accession Q9UJY4. Expected to cross-react with mouse.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- D3DWF0
- Synonyms:
- ADP-ribosylation factor-binding protein GGA2;gamma-adaptin-related protein 2;golgi-localized, gamma ear-containing, ARF-binding protein 2;VEAR;VHS domain and ear domain of gamma-adaptin;VHS domain and ear domain-containing protein
- Extra Details:
- GGA-2 plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. It mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain that mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins.
- Shipping Conditions:
- Dry Ice