600-101-MN4
Collagen Type IV Antibody
Cannot supply to this region.
- SKU:
- 600-101-MN4
- Additional Names:
- Arresten antibody, Canstatin antibody, Collagen Of Basement Membrane Alpha 1 Chain antibody, alpha unit Collagen IV Type IV Collagen, Col4, Collagen alpha-1(IV) chain|COL4A1
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1.18 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Goat
- Reactivities:
- Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Collagen IV antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near aa 240-265 of mouse Collagen IV.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- P02463
- Synonyms:
- alpha-1 type IV collagen;alpha1(IV) collagen;Br;Bru;Col4;Col4a-1;collagen alpha-1(IV) chain;Del(8)44;procollagen, type IV, alpha 1;R;Raw;S;Svc
- Extra Details:
- Collagens are highly conserved throughout evolution and are characterized by an uninterrupted ''Glycine-X-Y'' triplet repeat that is a necessary part of the triple helical structure. For these reasons, it is often extremely difficult to generate antibodies with specificities to collagens. The development of 'type' specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. Collagen Type IV proteins are integral components of basement membranes. This type of collagen is found primarily in the basal lamina. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen type IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause collagen IV to form in a sheet, the form of the basal lamina. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Anti-Collagen Type IV Antibody is ideal for researchers involved in extracellular matrix proteins and nephritis.
- Shipping Conditions:
- Dry Ice