600-101-MH8S
Doublecortin Antibody
Cannot supply to this region.
- SKU:
- 600-101-MH8S
- Additional Names:
- DCX|Goat Anti-Doublecortin Antibody, Lissencephalin-X, Doublecortex, Doublin, Lis-X, DBCN, LISX, Doublecortex Lissencephaly X-Linked (Doublecortin), Neuronal Migration Protein Doublecortin, SCLH, XLIS, DC
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1.3 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Goat
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Doublecortin antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human doublecortin conjugated to Keyhole Limpet Hemocyanin (KLH).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- O43602
- Synonyms:
- DBCN;DC;doublecortex;doublin;lis-X;lissencephalin-X;LISX;neuronal migration protein doublecortin;SCLH;XLIS
- Extra Details:
- DCX (Neuronal Migration Protein Doublecortin) is a microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. It may act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. In that way, it may participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. Doublecortin may be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Anti-Neuronal Migration Protein Doublecortin Antibody is useful for researcher interested in developmental biology, cytoskeletal signaling, neuroscience, and protein kinase binding.
- Shipping Conditions:
- Dry Ice