600-101-MH4
Mash1/Ascl1 Antibody
Cannot supply to this region.
- SKU:
- 600-101-MH4
- Additional Names:
- Ascl1|Goat Anti-Ascl1 Antibody, Goat Anti-Mash1 Antibody, Achaete-scute homolog 1, ASH-1, mASH-1
- Application:
- ELISA, IHC, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Goat
- Reactivities:
- Human, Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Mash1/Ascl1 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of mouse Mash1/Ascl1 conjugated to Keyhole Limpet Hemocyanin (KLH).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q02067
- Synonyms:
- achaete-scute complex homolog-like 1;achaete-scute complex-like protein 1;achaete-scute homolog 1;AI225900;AS;ASH1;bHLHa;bHLHa46;mammalian achaete scute homolog 1;Mas;Mash1
- Extra Details:
- Ascl1 (Achaete-scute homolog 1) is a transcription factor that plays a key role in neuronal differentiation, it acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. It directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Ascl1 plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. It is essential for the generation of olfactory and autonomic neurons. It acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Anti-Mash1/Ascl1 Antibody is useful for researchers interested in CCHS, SIDS, Dopaminergic Neurogenesis, and DNA binding.
- Shipping Conditions:
- Dry Ice