600-101-GU8
PDL1 Antibody
Cannot supply to this region.
- SKU:
- 600-101-GU8
- Additional Names:
- CD274|Goat anti-PDL1 antibody, Programmed cell death 1 ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, PD-L1, PDCD1 ligand 1, B7-H1, B7 homolog 1, PDL-1, CD274 molecule antibody, MGC142294 antibody, PDL 1
- Application:
- ELISA, Flow Cytometry, IHC, WB, IF, IP
- Concentration:
- 1.07 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Goat
- Reactivities:
- Human, Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Anti-PDL1 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human PDL1 conjugated to Keyhole Limpet Hemocyanin (KLH).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9NZQ7
- Synonyms:
- B7 homolog 1;B7-H;B7H1;CD274 antigen;hPD-L1;PD-L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;programmed cell death 1 ligand 1
- Extra Details:
- PDL1 belongs to the immunoglobulin superfamily and BTN/MOG family. PDL1 is involved in the costimulatory signal, essential for T-cell proliferation and production of IL-10 and IFNG, in an IL-2 dependent and a PDCD1 independent manner. It is up-regulated in T-and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. PDL1 is up-regulated in B-cells activated by surface Ig cross-linking. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Anti-PDL-1 Antibody is useful for researches interested in cancer research, NF-kB pathway research, and the Immune system.
- Shipping Conditions:
- Dry Ice