AIF Antibody

Cannot supply to this region.

SKU:: 200-401-X83
Additional Names:: AIF Antibody, Apoptosis-inducing factor 1, AIFM1, PDCD8|AIFM1
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-AIF antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the N-terminus of mature human AIF.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: O95381
Synonyms:: AIF;apoptosis-inducing factor 1, mitochondrial;apoptosis-inducing factor, mitochondrion-associated, 1;auditory neuropathy, X-linked recessive 1;AUNX1;CMT2D;CMTX4;CNK;CNK homolog protein 1;CNK1;connector enhancer of kinase suppressor of ras 1;connector enhancer of KSR 1;connector enhancer of KSR-like;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;programmed cell death 8 (apoptosis-inducing factor);SEMDHL;striatal apoptosis-inducing factor;testicular secretory protein Li 4
Extra Details:: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed.

Shipping Conditions:: Dry Ice