_Antibody_1_WB_4x3.JPG)
200-401-N98
AKT Antibody
Cannot supply to this region.
- SKU:
- 200-401-N98
- Additional Names:
- AKT1, AKT2, AKT3|rabbit anti-AKT antibody, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, RAC-alpha serine/threonine-protein kinase, Proto-oncogene c-Akt, AKT1 Antibody, AKT2 Antibody, AKT3 Antibody
- Application:
- ELISA, Flow Cytometry, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.5 M Sodium Chloride
- Immunogen:
- Anti-AKT Pan Reactive Antibody was produced in rabbits by repeated immunizations with a cocktail containing recombinant human AKT1, AKT2, and AKT3 protein isoforms.
- Formulation:
- 0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2
- Uniprot:
- P31749
- Synonyms:
- AKT;AKT1m;MPPH;MPPH2;PKB;PKB alpha;PKB gamma;PKB-ALPHA;PKB-GAMMA;PKBG;PRKBA;PRKBG;Protein kinase B;protein kinase B alpha;proto-oncogene c-Akt;RAC;rac protein kinase alpha;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-gamma;RAC-gamma serine/threonine protein kinase;RAC-gamma serine/threonine-protein kinase;RAC-PK-alpha;RAC-PK-gamma;serine-threonine protein kinase;STK-2;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma);v-akt murine thymoma viral oncogene-like protein 1
- Extra Details:
- AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as AKT1, Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. Anti-AKT Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience, Signal Transduction research.
- Shipping Conditions:
- Dry Ice