200-401-B60S
CCL2 Antibody
Cannot supply to this region.
- SKU:
- 200-401-B60S
- Additional Names:
- CCL2|rabbit anti-CCL2 antibody, CCL-2, CCL 2, Chemokine (C-C motif) ligand 2, monocyte chemotactic (or chemoattractant) protein-1 (MCP-1)
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Bovine
- Storage Conditions:
- -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Bovine
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein raised in yeast, corresponding to the 76 amino acids of the mature bovine CCL2 protein.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- A5PJF7
- Synonyms:
- acidic seminal fluid protein;C-C motif chemokine 2;MCP-1;MCP-1A;MCP1;MCP1A;monocyte chemoattractant protein 1;monocyte chemotactic protein 1;monocyte chemotactic protein 1A;SCYA2;small-inducible cytokine A2
- Extra Details:
- CCL2 is a small cytokine belonging to the CC chemokine family that recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing a signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a total molecular weight of approximately 8.8 kDa. The cell surface receptors that bind CCL2 are CCR2 and CCR4. CCL2 is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor kB (NFkB). In human osteoclasts, CCL2 and RANTES (regulated on activation normal T cell expressed and secreted) may act as an autocrine loop in human osteoclast differentiation. CCL2 causes the degranulation of basophils and mast cells, an effect potentiated by pre-treatment with IL-3 and other cytokines.
- Shipping Conditions:
- Dry Ice