200-401-A67
TIRAP Antibody
Cannot supply to this region.
- SKU:
- 200-401-A67
- Additional Names:
- Adapter protein wyatt antibody, FLJ42305 antibody, MAL antibody, MyD88 adapter like protein antibody, TIR domain containing adapter protein antibody, Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody|TIRAP
- Application:
- ELISA, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Mouse
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- TIRAP Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the C-terminus of mouse TIRAP.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q99JY1
- Synonyms:
- AA407980;adaptor protein Wyatt;C130027E04Rik;M;Mal;myD88 adapter-like protein;TIR domain-containing adapter protein;Tlr4ap;Toll-like receptor 4 adaptor protein;toll/interleukin-1 receptor domain-containing adapter protein;wyat;Wyatt
- Extra Details:
- Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP (Toll-interleukin 1 receptor domain-containing adaptor protein) and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 or TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling. Anti-TIRAP antibody is ideal for investigators involved cytokines and growth factors research.
- Shipping Conditions:
- Dry Ice