ASPP2 Antibody

Cannot supply to this region.

SKU:: 200-401-A19
Additional Names:: rabbit anti-ASPP2 antibody, ASPP-2, ASPP 2, Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody, Tumor suppressor p53-binding protein 2, TP53BP2|TP53BP2
Application:: ELISA, IHC, WB
Concentration:: 2.4 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human ASPP2.
Formulation:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Uniprot:: Q13625
Synonyms:: 53BP2;apoptosis-stimulating of p53 protein 2;apoptosis-stimulating protein of p53, 2;ASPP2;BBP;BCL2-binding protein;P53BP2;PPP1R13A;renal carcinoma antigen NY-REN-51;tumor suppressor p53-binding protein 2
Extra Details:: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.

Shipping Conditions:: Dry Ice