CD27 Phycoerythrin Antibody

Cannot supply to this region.

SKU:: 200-308-N65
Additional Names:: CD27|CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, CD27, TNFRSF7
Application:: Flow Cytometry
Concentration:: 0.05 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C unopened. Protect from light.
Supplier:: Rockland Inc
Host:: Mouse
Reactivities:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride
Immunogen:: Anti-CD27 Antibody (Monoclonal) was produced by repeated immunizations with CD27 antigen.
Formulation:: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Clone:: O323
Uniprot:: P26842
Synonyms:: CD27 antigen;CD27L receptor;S152;S152. LPFS2;T cell activation antigen S152;T-cell activation antigen CD27;T14;TNFRSF7;Tp55;Tumor necrosis factor receptor superfamily member 7;tumor necrosis factor receptor superfamily, member 7
Extra Details:: CD27 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells. The CD27 antibody may be used for analysis of CD27 expression on peripheral T cells, and is frequently used in combination with antibodies for IgD and IgM to distinguish naive vs. memory B cell populations. For identification of Breg cells, this antibody has been used in combination with antibodies for CD25, CD27, CD1d, IL-10 and TGF-beta.

Shipping Conditions:: Blue Ice