CD8a Phycoerythrin Antibody

Cannot supply to this region.

SKU:: 200-308-N62
Additional Names:: CD8A|T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a
Application:: Flow Cytometry, IHC, IP
Concentration:: 0.012 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C unopened. Protect from light.
Supplier:: Rockland Inc
Host:: Mouse
Reactivities:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride
Immunogen:: Anti-CD8a Antibody (Monoclonal) was produced by repeated immunizations with CD8a antigen.
Formulation:: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Clone:: OKT8
Uniprot:: P01732
Synonyms:: CD8;CD8 antigen, alpha polypeptide (p32);Leu2;Leu2 T-lymphocyte antigen;OKT8 T-cell antigen;p32;T cell co-receptor;T-cell antigen Leu2;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu-2;T8 T-cell antigen
Extra Details:: The OKT8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. The OKT8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Shipping Conditions:: Blue Ice