200-301-P29
CDC6 Antibody
Cannot supply to this region.
- SKU:
- 200-301-P29
- Additional Names:
- CDC18L, HsCdc18, p62(cdc6), CELL DIVISION CYCLE 18, S. POMBE, HOMOLOG-LIKE, CDC6 (cell division cycle 6, S. cerevisiae) homolog, CELL CYCLE CONTROLLER CDC6, CDC6-related protein, Cdc18-related protein|CDC6
- Application:
- ELISA, WB
- Concentration:
- 1 mg/ml
- Physical State:
- Lyophilized
- Species Reactivity:
- Human
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Rockland Inc
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- 1.2% sodium acetate
- Immunogen:
- CDC6 antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to human Cdc6.
- Formulation:
- 1.2% sodium acetate
- Clone:
- DCS-180
- Uniprot:
- Q99741
- Synonyms:
- cdc18-related protein;CDC18L;CDC6 cell division cycle 6 homolog;CDC6-related protein;cell division control protein 6 homolog;cell division cycle 6 homolog;HsCDC18;HsCDC6;MGORS5;p62(cdc6)
- Extra Details:
- In yeasts, Cdc6 (Saccharomyces cerevisiae) and Cdc18 (Schizosaccharomyces pombe) associate with the origin recognition complex (ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al. (1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells. This antibody is suitable for researchers interested in cancer research and Cell Cycle research.
- Shipping Conditions:
- Ambient