200-301-I29
TLR7 Antibody
Cannot supply to this region.
- SKU:
- 200-301-I29
- Additional Names:
- TLR7|Toll-like receptor 7
- Application:
- Flow Cytometry, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- TLR7 Antibody was produced in mice prepared by repeated immunizations with an internal portion of human TLR7 recombinant protein.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Clone:
- IMG4G6
- Uniprot:
- Q9NYK1
- Synonyms:
- IMD74;TLR7-like;toll-like receptor 7;toll-like receptor 7-like
- Extra Details:
- Anti-TLR7 Antibody detects human TLR7. TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Anti-TLR7 Antibody is ideal for investigators that are involved in cytokin and grow factor research.
- Shipping Conditions:
- Dry Ice