200-301-H87
IKK gamma Antibody
Cannot supply to this region.
- SKU:
- 200-301-H87
- Additional Names:
- FIP3, NEMO, NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier|IKBKG
- Application:
- WB
- Concentration:
- 0.5 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Mouse
- Reactivities:
- Human, Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- IKK gamma Antibody was produced in mice prepared by repeated immunizations with full-length human NEMO protein (IKKgamma).
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Clone:
- 72C627
- Uniprot:
- Q9Y6K9
- Synonyms:
- 14.7K (adenovirus E3 protein) interacting protein 3;AMCBX1;EDAID1;FIP-3;FIP3;Fip3p;I-kappa-B kinase subunit gamma;ikB kinase subunit gamma;ikB kinase-associated protein 1;IKK-gamma;IKKAP1;IKKG;IMD33;incontinentia pigmenti;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma;inhibitor of nuclear factor kappa B kinase subunit gamma;Inhibitor of nuclear factor kappa-B kinase subunit gamma;IP;IP1;IP2;IPD2;NEMO;NF-kappa-B essential modifier;NF-kappa-B essential modulator;ZC2HC9
- Extra Details:
- Anti-IKKgamma Antibody detects human IKKgamma. NF-kappaB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kappaB thereby preventing translocation of to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKKalpha, IKKbeta, and IKK gamma. IKK gamma, also named NEMO from NF-kB Essential MOdulator, preferentially interacts with IKKbeta and is required for activation of IKK complex. Recent data suggest that the human Tcell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKKa nor IKKb, but complexes directly with IKK gamma (NEMO). This suggests that IKK gamma (NEMO) may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb. Anti-IKKgamma Antibody is ideal for investigators involved in NFkappaB, kinase and growth factor research.
- Shipping Conditions:
- Dry Ice