200-301-H84
IKK beta Antibody
Cannot supply to this region.
- SKU:
- 200-301-H84
- Additional Names:
- IKBKB|IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, 2.7.11.10, I-kappa-B kinase , IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB
- Application:
- Flow Cytometry, IHC, WB, IF, IP
- Concentration:
- 0.5 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Storage Conditions:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- IKK beta Antibody was produced in mice prepared by repeated immunizations with IKK beta, recombinant human protein.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Clone:
- 10A9B6
- Uniprot:
- O14920
- Synonyms:
- I-kappa-B kinase 2;I-kappa-B-kinase beta;IKK-beta;IKK2;IKKB;IMD15;IMD15A;IMD15B;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta;NFKBIKB;nuclear factor NF-kappa-B inhibitor kinase beta;serine/threonine protein kinase IKBKB
- Extra Details:
- Anti-IKKb IKK2 Antibody detects human IKKb IKK2. NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/alpha, IKK2/beta, and IKK3/gamma. IKK1/alpha and IKK beta are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK beta, not IKK1/alpha, is the target proinflammatory stimuli. Targeted disruption of IKK beta gene in mice also results in extensive liver damage from apoptosis and death as embryo. Anti-IKKb IKK2 Antibody is ideal for investigators involved in kinase and growth factor research.
- Shipping Conditions:
- Dry Ice