PUMA Antibody [2A8F6]

Cannot supply to this region.

SKU:: 200-301-DV3
Additional Names:: BBC3|PUMA Antibody [2A8F6], JFY1, PUMA, JFY-1
Application:: ELISA, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Mouse
Reactivities:: Human, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-PUMA antibody was produced In mice by repeated immunizations with a recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Clone:: 2A8F6
Uniprot:: Q9BXH1
Synonyms:: bcl-2-binding component 3;JFY-1;JFY1;p53 up-regulated modulator of apoptosis;p53-upregulated modulator of apoptosis;PUMA
Extra Details:: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa and PUMAb. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Shipping Conditions:: Dry Ice