PD-1 Antibody [7A11B1]

Cannot supply to this region.

SKU:: 200-301-DK3
Additional Names:: PD-1 Antibody [7A11B1] , PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1|PDCD1
Application:: ELISA, IHC, WB, IF
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Mouse
Storage Conditions:: 2-8[o]C
Supplier:: Rockland Inc
Host:: Mouse
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-PD-1 antibody was produced in mice by repeated immunizations with a ~150 amino acid recombinant protein from near the N-terminus of mouse PD-1.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Clone:: 7A11B1
Uniprot:: Q15116
Synonyms:: CD279;hPD-1;hPD-l;hSLE1;PD-1;PD1;programmed cell death 1 protein;programmed cell death protein 1;protein PD-1;SLEB2;systemic lupus erythematosus susceptibility 2
Extra Details:: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Shipping Conditions:: Blue Ice