KLF4 Antibody [4E5C3]

Cannot supply to this region.

SKU:: 200-301-CE9
Additional Names:: KLF4|KLF4 Antibody [4E5C3] , EZF, GKLF
Application:: ELISA, WB
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Mouse
Reactivities:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-KLF4 antibody was produced in mice by repeated immunizations with a 20 amino acid synthetic peptide near the C-terminus of human KLF4.
Formulation:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Clone:: 4E5C3
Uniprot:: O43474
Synonyms:: endothelial Kruppel-like zinc finger protein;epithelial zinc finger protein EZF;EZF;GKLF;gut Kruppel-like factor;gut-enriched krueppel-like factor;Krueppel-like factor 4;Kruppel-like factor 4 (gut)
Extra Details:: KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.

Shipping Conditions:: Dry Ice