IKB beta Antibody

Cannot supply to this region.

SKU:: 100-4186
Additional Names:: NFKBIB|rabbit anti-IKB beta Antibody, NF kappa BIB antibody, NFKBIB antibody, Thyroid receptor interacting protein 9 antibody, TR interacting protein 9 antibody, TRIP9 antibody
Application:: ELISA, WB
Concentration:: 100 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: IkBb peptide corresponding to a region near the C-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Format:: Antiserum
Uniprot:: Q15653
Synonyms:: I-kappa-B-beta;ikappaBbeta;ikB-B;ikB-beta;IKBB;NF-kappa-B inhibitor beta;NF-kappa-BIB;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta;thyroid receptor-interacting protein 9;TR-interacting protein 9;TRIP-9;TRIP9
Extra Details:: NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.

Shipping Conditions:: Dry Ice