CBFb Antibody

Cannot supply to this region.

SKU:: 100-401-V32
Additional Names:: CBFB|Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
Application:: ChIP, ELISA
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Immunogen:: Anti-CBFb Antibody was produced in rabbits by repeated immunizations with human CBFb using two synthetic peptides containing sequences from the internal region of the protein.
Format:: Antiserum
Uniprot:: Q13951
Synonyms:: CBF-beta;core-binding factor beta subunit;core-binding factor subunit beta;PEA2-beta;PEBP2-beta;PEBP2B;polyomavirus enhancer binding protein 2, beta subunit;Polyomavirus enhancer-binding protein 2 beta subunit;SL3-3 enhancer factor 1 beta subunit;SL3-3 enhancer factor 1 subunit beta;SL3/AKV core-binding factor beta subunit
Extra Details:: CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Anti-CBFb Antibody is ideal for research in Gene Expression, Cell Differentiation and Cancer.

Shipping Conditions:: Dry Ice