100-401-A21
cKrox Antibody
Cannot supply to this region.
- SKU:
- 100-401-A21
- Additional Names:
- c-KROX|rabbit anti-cKrox Antibody, ThPok antibody, Kruppel related zinc finger protein hcKrox antibody, T-helper inducing POZ/Kruppel-like factor antibody, ZBTB 15 antibody, ZBTB 7B antibody
- Application:
- ELISA, IHC, WB
- Concentration:
- 85 mg/ml
- Physical State:
- Lyophilized
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C liquid. Aliquot. Avoid freeze/thaw cycles., -20[o]C/-70[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Rockland Inc
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of mouse cKrox protein.
- Formulation:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Format:
- Antiserum
- Uniprot:
- Q64321
- Synonyms:
- c-Kr;c-Krox;krueppel-related zinc finger protein cKrox;T-helper-inducing POZ/Krueppel-like factor;Thp;Thpok;Vzinc finger and BTB domain containing 7B;Zfp6;Zfp67;zinc finger and BTB domain-containing protein 7B;zinc finger protein 67;zinc finger protein Th-POK
- Extra Details:
- This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-cKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.
- Shipping Conditions:
- Ambient