Cul5 Antibody

Cannot supply to this region.

SKU:: 100-401-A05
Additional Names:: CUL5|rabbit anti-Cul5 Antibody, rabbit anti-Cullin5 antibody, VACM 1 antibody, VACM1 antibody, Vasopressin activated calcium mobilizing receptor 1 antibody, Vasopressin activated calcium mobilizing receptor antibody, CUL, Cullin
Application:: ELISA, IHC, WB, IF, IP
Concentration:: 85 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Storage Conditions:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Supplier:: Rockland Inc
Host:: Rabbit
Reactivities:: Human
Immunogen:: This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an N-Terminal region near amino acids 1-25 of Human Cul5 (N-terminus) coupled to KLH.
Format:: Antiserum
Uniprot:: Q93034
Synonyms:: CUL-5;cullin-5;Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1);VACM-1;VACM1;vasopressin-activated calcium-mobilizing receptor 1;Vasopressin-activated calcium-mobilizing receptor-1
Extra Details:: Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 5 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 5 seems to be involved proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Cullin 5 may form a cell surface vasopressin receptor. Cullin 5 is part of a E3 ubiquitin ligase complex with elongin BC complex (TCEB1 and TCEB2), RBX1 and MUF1, complexes with elongin BC complex (TCEB1 and TCEB2), RXB1 and TCEB3 or SOCS1 or WSB1; elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL; elongin BC complex (TCEB1 and TCEB2), RBX1, adenovirus type 5 E1B-55kDa protein and adenovirus type 5 E4-orf6. Cullin 5 Interacts with RBX1 and RNF7.

Shipping Conditions:: Dry Ice